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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2B All Species: 42.73
Human Site: T477 Identified Species: 67.14
UniProt: Q02880 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02880 NP_001059.2 1626 183267 T477 G K H S L E C T L I L T E G D
Chimpanzee Pan troglodytes XP_516332 1634 184611 T485 G K H S L E C T L I L T E G D
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 T471 G K H S L E C T L I L T E G D
Dog Lupus familis XP_534241 2041 231068 T895 G K H S L E C T L I L T E G D
Cat Felis silvestris
Mouse Mus musculus Q64511 1612 181890 T465 G K H S L E C T L I L T E G D
Rat Rattus norvegicus P41516 1526 173202 T454 S R N S A E C T L I L T E G D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507216 1923 216719 T780 G K H S L E C T L I L T E G D
Chicken Gallus gallus O42131 1627 183228 T482 G K H S L D C T L I L T E G D
Frog Xenopus laevis NP_001082502 1579 178601 T454 S R N S L E C T L I L T E G D
Zebra Danio Brachydanio rerio NP_001038656 1618 182448 T476 G K H S S E C T L I L T E G D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 E390 M S K S G I V E S V L A W A K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 S463 D D L N K K C S K T K T S K L
Sea Urchin Strong. purpuratus XP_783546 1448 163750 C391 H I W V F V N C A I E N P T F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 W416 V V E N L L S W A D F K Q N K
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 T371 S Q T K E Q L T T R V K D F G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.5 78.1 N.A. 95.6 66.2 N.A. 79.3 89.2 66.6 73.6 N.A. 50.3 N.A. 49.5 57.3
Protein Similarity: 100 98.5 99.1 78.8 N.A. 97.2 78.1 N.A. 81.8 93.8 78.7 83.8 N.A. 64.3 N.A. 65.8 69.9
P-Site Identity: 100 100 100 100 N.A. 100 73.3 N.A. 100 93.3 80 93.3 N.A. 13.3 N.A. 13.3 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 86.6 N.A. 100 100 93.3 93.3 N.A. 20 N.A. 33.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. 43.3 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 59 56.8 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 7 0 0 0 14 0 0 7 0 7 0 % A
% Cys: 0 0 0 0 0 0 74 7 0 0 0 0 0 0 0 % C
% Asp: 7 7 0 0 0 7 0 0 0 7 0 0 7 0 67 % D
% Glu: 0 0 7 0 7 60 0 7 0 0 7 0 67 0 0 % E
% Phe: 0 0 0 0 7 0 0 0 0 0 7 0 0 7 7 % F
% Gly: 54 0 0 0 7 0 0 0 0 0 0 0 0 67 7 % G
% His: 7 0 54 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 0 0 7 0 0 0 74 0 0 0 0 0 % I
% Lys: 0 54 7 7 7 7 0 0 7 0 7 14 0 7 14 % K
% Leu: 0 0 7 0 60 7 7 0 67 0 74 0 0 0 7 % L
% Met: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 14 14 0 0 7 0 0 0 0 7 0 7 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % P
% Gln: 0 7 0 0 0 7 0 0 0 0 0 0 7 0 0 % Q
% Arg: 0 14 0 0 0 0 0 0 0 7 0 0 0 0 0 % R
% Ser: 20 7 0 74 7 0 7 7 7 0 0 0 7 0 0 % S
% Thr: 0 0 7 0 0 0 0 74 7 7 0 74 0 7 0 % T
% Val: 7 7 0 7 0 7 7 0 0 7 7 0 0 0 0 % V
% Trp: 0 0 7 0 0 0 0 7 0 0 0 0 7 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _